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CLOTHOLINE


clotholineClotholine ® promotes longevity of the skin by activating the synthesis of Klotho the « youth hormone ».

Klotho, a protein whose name is derived from the Greek goddess Clotho in charge of spinning the thread of life, is of particular interest for the life science community. Klotho inhibits the signalization pathway of insulin/IGF-1 and Wnt. Klotho increases resistance to oxidative stress and delay senescence1,2. Klotho also regulates the metabolism of calcium and vitamin D3 3. All these mechanisms help to fight against  aging

Several studies have demonstrated the protective effect of Klotho on living beings. On one hand, overexpression of Klotho in mouse increases lifespan2, on the other hand its absence results in premature aging, notably in the skin. In human beings, alteration of Klotho increases the risk of developing cancers, hepatic or cardiovascular diseases4… In general, a reduction of Klotho expression is associated with poor prognosis of survival; its presence is essential…

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